PerioMonitor™ is a rapid, non-invasive, in-office, saliva-based test. It measures the patient’s leukocyte esterase level that is associated with active periodontal disease. PerioMonitor™ does not require a laboratory or device.PerioMonitor™ est un test rapide, non-invasif, effectué en clinique à partir de la salive. Il mesure le niveau d’estérase leucocytaire, un marqueur associé à une maladie parodontale active. PerioMonitor™ ne nécessite aucun envoi en laboratoire ou appareil.
375 patients in 4 dental offices375 patients dans 4 cliniques dentaires
Test results were compared to the Bleeding on Probing (BOP) methodLes résultats des tests ont été comparés à la méthode du saignement au sondage (BOP)
PerioMonitor™ has been developed under the leadership and research of Dr. Michael Glogauer, a renowned Toronto-based periodontist, Chief of Dentistry for the University Health Network and Head of Dental Oncology at the Princess Margaret Cancer Centre.PerioMonitor™ a été mis au point sous la direction et les recherches du Dr Michael Glogauer, un parodontiste renommé basé à Toronto, Chef du service de dentisterie de l’University Health Network et Responsable de l'oncologie dentaire au Princess Margaret Cancer Centre.
“PerioMonitor is the missing link in patient periodontal treatment acceptance, aligning with Oral Science’s mission to provide evidence-based solutions that enhance clinical outcomes.”«PerioMonitor est le maillon manquant dans l'acceptation du traitement parodontal par les patients, s'alignant sur la mission de Oral Science : fournir des solutions fondées sur des preuves scientifiques afin d'améliorer les résultats cliniques.»
— Daniel Ménard, CEO & Co-Founder of Oral Science, Distributor of PerioMonitor™président et co-fondateur de Oral Science, distributeur de PerioMonitor™
In conclusion, just as the simple Blood Pressure Cuff has become indispensable for physicians managing hypertension, PerioMonitorTM may prove to be an equally indispensable tool for dental professionals in their efforts to diagnose periodontal diseases, monitor treatment effectiveness, track disease progression, and deliver proactive patient care to everyone. The device will enhance clinical decision-making, optimize treatment outcomes, and contribute to the overall well-being of patients.
Elebyary, O., & Glogauer, M. (2023). Monitoring Oral Inflammation: A Chairside Game-changer. Oral Health Group. https://www.oralhealthgroup.com/features/monitoring-oral-inflammation-a-chairside-game-changer/
Oral neutrophil levels, as determined by a rapid oral rinse, reflect the severity of periodontal disease and treatment response. A single, rapid, oral rinse assay is an effective means of collecting and quantifying oral neutrophil levels and may serve as an excellent research tool for further study of the role of neutrophils in periodontal diseases.
Bender, J. S., Thang, H., & Glogauer, M. (2006). Novel Rinse Assay for the Quantification of Oral Neutrophils and the Monitoring of Chronic Periodontal Disease. Journal of Periodontal Research, 41(3), 214–220. https://doi.org/10.1111/j.1600-0765.2005.00861.x
The rinse assay can be used as a screening tool for oral inflammation, which was also related to the presence of periodontitis, in pregnant females attending a medical clinic.
Huda, S., Doering, H., Tenenbaum, H. C., Whittle, W., Sigal, M. J., & Glogauer, M. (2015). Oral Neutrophil Levels: A Screening Test for Oral Inflammatory Load in Pregnancy in a Medical Setting. Journal of Periodontology, 86(1), 72–81. https://doi.org/10.1902/jop.2014.140116
PerioMonitor™ represents a paradigm shift in periodontal disease management. By offering real-time insights into oral inflammation, it advances the dental profession’s capacity for early detection, individualized care, and improved patient communication. For DSOs, it provides a scalable, cost-effective tool that enhances operational excellence and elevates the standard of care across all locations.
Oral Science. (2025). PerioMonitor™ - A Game-Changer in Chairside Oral Inflammation Detection [White paper].
Oral neutrophil testing represents a new frontier in preventive and periodontal care offering clinicians and clients alike a real-time window into inflammatory status. By providing rapid, objective, and noninvasive results, PerioMonitor™ aligns with the future of personalized oral health care and supports a shift from reactive treatment to proactive prevention.
Glogauer, M. (2025). erioMonitor™: Advancing Chairside Detection of Periodontal Inflammation Through Neutrophil Quantification. FOCUS (Ontario Dental Hygienists' Association), 29(3), 11–13.
oPMN level can be used to differentiate between grade B and C periodontitis. Likewise, the presence of periodontal pathogens Pg and Pi correlated with the oPMN level. Given these findings, oPMN level may be useful as a multipurpose clinical biomarker in terms of diagnosing periodontitis and determining the risk of disease progression.
Prete, B. R. J., Barbour, A., Sun, C., Tenenbaum, H. C., Goldberg, M. B., & Glogauer, M. (2025). Prognostic Utility of Oral Neutrophil Counts in High-Risk Periodontitis: A Retrospective Study. Journal of Periodontology, 1–14. https://doi.org/10.1002/jper.11360
Oral polymorphonuclear neutrophil (oPMN) counts obtained through a 30-s oral rinse are a good marker of oral inflammatory load and correlate with measures of periodontal disease severity.
Landzberg, M., Doering, H., Aboodi, G. M., Tenenbaum, H. C., & Glogauer, M. (2015). Quantifying Oral Inflammatory Load: Oral Neutrophil Counts in Periodontal Health and Disease. Journal of Periodontal Research, 50(3), 330–336. https://doi.org/10.1111/jre.12211
Due to the association of oral neutrophils with periodontal disease, and the ready availability of neutrophils in human saliva, these immune cells represent a significant opportunity for therapeutic intervention and as biomarkers in oral disease, whose potential has only just begun to be exploited.
Fine, N., & Glogauer, M. (2021). The Neutrophil in Oral Health and Disease: The New Diagnostic Biomarker. Oral Health Group. https://www.oralhealthgroup.com/features/the-neutrophil-in-oral-health-and-disease-the-new-diagnostic-biomarker/
In health, PMNs are constitutively recruited to mucosal tissues, including the oral cavity, gastrointestinal, respiratory and reproductive tracts and the ocular surface, and a lesser extent to naive sterile tissues throughout the body. Future research using new cutting-edge approaches, such as single cell RNAseq, mass cytometry and intravital microscopy, will help to develop a deeper understanding of PMN subset diversity and new opportunities for therapeutic intervention.
Fine, N., Tasevski, N., McCulloch, C. A., Tenenbaum, H. C., & Glogauer, M. (2020). The Neutrophil: Constant Defender and First Responder. Frontiers in Immunology, 1—15. https://doi.org/10.3389/fimmu.2020.571085
The NEA strip is a user-friendly and rapid screening tool for detecting high ONCs associated with periodontal inflammation and for evaluating the effectiveness of periodontal therapy.
Elebyary, O., Sun, C., Batistella, E. A., Van Dyke, T. E., Low, S. B., Singhal, S., Tenenbaum, H., & Glogauer, M. (2024). Utilizing Oral Neutrophil Counts as an Indicator of Oral Inflammation Associated With Periodontal Disease: A Blinded Multicentre Study. Journal of Clinical Periodontology, 1–11. https://doi.org/10.1111/jcpe.14054
PerioMonitor measures oral neutrophils—white blood cells released in response to local inflammation in the mouth. It provides an objective snapshot of oral inflammation from conditions like gingivitis, periodontitis, or peri-implant disease.PerioMonitor mesure les neutrophiles buccaux — des globules blancs libérés en réponse à une inflammation locale dans la bouche. Il offre un aperçu objectif de l’inflammation buccale liée à des affections comme la gingivite, la parodontite ou la maladie péri-implantaire.
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No. The test is accurate if you follow the 15 second pre-rinse and 2 minute wait.Non. Le test est fiable si vous respectez le prélavage de 15 secondes et l’attente de 2 minutes.
Yes. Peri-implant disease often causes more inflammation—monitor implants closely.Oui. La maladie péri-implantaire provoque souvent davantage d’inflammation—surveillez les implants de près.
No. But these conditions can worsen oral inflammation, which PerioMonitor detects.Non. Mais ces affections peuvent aggraver l’inflammation buccale, que PerioMonitor détecte.
No. They may reduce symptoms, but PerioMonitor still detects true inflammation.Non. Ils peuvent atténuer les symptômes, mais PerioMonitor détecte toujours l’inflammation réelle.
No. They don’t affect oral neutrophils, so the test remains accurate.Non. Ils n’affectent pas les neutrophiles buccaux, le test reste donc fiable.
No direct effect, but these can raise oral inflammation, which may increase results.Pas d’effet direct, mais ils peuvent accroître l’inflammation buccale, ce qui peut augmenter les résultats.
Immunosuppression is a broad term that may result from medications, genetic conditions, or underlying disease. In immunosuppressed individuals,PerioMonitor™ results may be affected by variations in immune response, white blood cell profiles, and neutrophil function or migration. Despite this, PerioMonitor™ is still recommended, as establishing a personal baseline with repeat testing can help account for individual variability.L’immunosuppression est un terme général qui peut résulter de médicaments, de conditions génétiques ou de maladies sous-jacentes. Chez les individus immunosupprimés, les résultats du PerioMonitor™ peuvent être influencés par des variations de la réponse immunitaire, des profils de globules blancs ainsi que de la fonction ou de la migration des neutrophiles. Malgré cela, l’utilisation du PerioMonitor™ demeure recommandée, car l’établissement d’une référence personnelle grâce à des tests répétés permet de mieux tenir compte de la variabilité individuelle.
No. The test fluid captures neutrophils from gingival crevices—not saliva.Non. Le fluide du test capture les neutrophiles provenant des sillons gingivaux—pas la salive.
Only if it’s actively bleeding—otherwise, no effect.Uniquement en cas de saignement actif—sinon, aucun effet.
Only if pus or exudate is draining into the mouth—it contains neutrophils.Uniquement s’il existe un écoulement de pus/exsudat dans la bouche—il contient des neutrophiles.
It could be early gingivitis (initial preclinical stage) or other causes like candidiasis, oral cancer, or lichen planus. Retest in 4 weeks if unclear.Il peut s’agir d’une gingivite précoce (stade préclinique initial) ou d’autres causes comme une candidose, un cancer buccal ou un lichen plan. Refaire le test dans 4 semaines si le doute persiste.
Usually at 4–6 weeks, or as early as 2 weeks if needed.Habituellement après 4 à 6 semaines, ou dès 2 semaines si nécessaire.
Yes. Conditions like denture trauma can raise inflammation. It's a good tool for motivating better hygiene habits.Oui. Des situations comme les traumatismes liés aux prothèses peuvent accroître l’inflammation. C’est un bon outil pour motiver de meilleures habitudes d’hygiène.
A sinus infection will NOT affect a PM result. For teeth with non-reversible pulpitis: if the infection is contained within the tooth, it will not affect PerioMonitor™. If the tooth has a draining fistula, it will affect PerioMonitor™—exudate is full of neutrophils.Une sinusite n’affectera PAS le résultat PM. Pour une dent avec pulpite irréversible : si l’infection est confinée à la dent, elle n’affectera pas PerioMonitor™. Si la dent présente une fistule drainante, cela affectera PerioMonitor™—l’exsudat est riche en neutrophiles.
Contact Dr. Michael Glogauer: Contactez Dr Michael Glogauer : michael.glogauer@dentistry.utoronto.ca